A biodegradable adamantane polymer with ketal linkages in its backbone for gene therapy.
نویسندگان
چکیده
In this report we present a polyketal, termed pADK, which has adamantane groups embedded in its backbone, and degrades into neutral excretable compounds. pADK was synthesized via click chemistry and had a MW of 49 472 and a PDI of 1.74. We demonstrate here that pADK can increase the transfection efficiency of CD1800 (PEI of 1800 modified β-cyclodextrin) 60 fold, yet cause no increase in toxicity.
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عنوان ژورنال:
- Chemical communications
دوره 51 88 شماره
صفحات -
تاریخ انتشار 2015